AcquiredvonWillebrandsyndromeandfactorVIIIinpatientswithmoderatetoseveremitralregurgitationundergoingtranscathetermitralvalverepairClinicalCardiologyArticleEarlyRecent,Dec29,./clc.本文由“天纳”临床学术信息人工智能系统自动翻译点击文末“阅读原文”下载本文PDFBackgroundandHypothesisTheacquiredvonWillebrandsyndrome(AvWS),whichpredisposestobleedingevents,isoftenrelatedtovalvularheartdiseases.WeinvestigatedpossibleimplicationsofAvWSandfactorVIIIlevelsinpatientswithmoderatetoseveremitralregurgitation(MR)undergoingtranscathetermitralvalverepair(TMVR).获得性血管性血友病综合征（AvWS）易发生出血，常与瓣膜性心脏病有关。我们研究了中度至重度二尖瓣反流患者的二尖瓣关闭不全（AvWS）和二尖瓣关闭不全的可能影响。MethodsandResultspatientswithmoderatetosevereMRwereprospectivelyenrolled.CompletemeasurementsofvonWillebrandFactoractivity(vWFAct),vonWillebrandFactorantigen(vWFAg),andfactorVIIIexpressionbeforeand4?weeksafterTMVRwereavailablein85patients.Atbaseline,sevenpatientshadahistoryofgastrointestinalbleeding,twopatientssufferedbleedingeventsduringtheirhospitalstay,andonepatienthadableeding4?weeksafterTMVR.EventhoughvWFAct,vWFAct/vWFAgratioandvWFAgvaluesdidnotchangeafterTMVR,weobservedasignificantlylowervWFAct/vWFAgratioinpatientswithprimaryMRas
